Multivariate analysis and mathematical modeling of the informativeness of patients cases data in chronic pancreatitis associated with concomitant pathology.

OBJECTIVE: Aim: To investigate and analyze homeostatic disorders in patients with a combination of Chronic Pancreatitis(CP) and Arterial Hypertension (AH) and to develop correcting ways of the detected changes. PATIENTS AND METHODS: Materials and Methods: General clinical, laboratory-instrumental examination of 121 patients, who were undergoing inpatient treatment with a diagnosis of Chronic Pancreatitis in combination with Arterial Hypertension of the II stage during 2021-2022. RESULTS: Results: In the majority of cases of patients signs the increasing in IL-1,6 and Cortisol levels were found. A decrease in Ca to the lower limit of the norm was observed (2.18 ± 0.26 mmol/l to the data of control group patients (2.32 ± 0.12 mmol/l, p= 0.01 ), the levels of trace elements Zn and Se were determined within the reference values. The Atherogenic Index was increased 1.8 times and was significantly different from the control group date. During the FE-1 study, a decrease in the level of this indicator was revealed by 151.71±13.91 mg/g of feces, both to the values of reference values and a significant difference to the data of the control group (241.28±29.17 mg/g of feces, p<0 .05). CONCLUSION: Conclusions: Based on the multivariate linear regression analysis of the obtained data, formulas have been developed that can be used to predict the dynamics of the dependent variable (FE-1, IL-1, Selenium level, Glutathione Peroxidase, blood pressure) according to changes in the studied influencing factors.

IMMUNE-INFLAMMATORY-ENDOCRINE REGULATION DISORDERS IN CHILDREN WITH CORONAVIRUS INFECTION.

OBJECTIVE: The aim: To study the of homeostasis links desorder and indicators imbalance in children with Coronavirus infection. PATIENTS AND METHODS: Materials and methods: A clinical and laboratory study was conducted in children (50 persons) with Coronavirus infection. The children were used outpatient treatment. RESULTS: Results: It was found that Direct bilirubin was increased in 3 times (10.55±7.67 vs. 3.63±0.49 µmol/l, p<0.01), Alanine aminotransferase - in 1.7 times (37,02±20.53 vs. 21.90±1.82 IU/l, p<0.01). An levels increassng of Ig G - in 12.3 times, Ig E - in 4.6 times, Ig M - in 3.4 times was observed. The CRP level was increased in 3.1 times (8.76 ± 2.16 vs. 2.54 ± 0.53 mg/l, p< 0.01), C-peptide (4.65±1.67 vs. 1.23±0.08 ng/ml, p<0.01) - in 3.8 times. Negative correlations of T3 with Procalcitonin (r=-0.30) and Creatinine (r=-34) were revealed. T4 values are correlated with Total cholesterol (r=-0.65) and Creatinine (r=0.29). Leptin was presented positive correlations with Alanine aminotransferase (r=0.48) and with C-peptide (r=0.39). CONCLUSION: Conclusions: There was an increase in the Ig G levels in 12.3 times, Ig E - in 4.6 times, and the Ig M level - in 3.4 times. The Thyroid stimulating hormone level was significantly lower (in 4.7 times). An increase in the C-reactive protein levels (in 3.1 times) and C-peptide (in 3.8 times) was observed. It should be noted that the strongest negative correlation between T4 and Total cholesterol (r=-0.65) and the highest positive correlation between Leptin and Alanine aminotransferase (r=0.48) and C-peptide (r=0. 39).

PAIN SYNDROM IN CASES OF PATIENTS WITH A COMBINATION OF CHRONIC PANCREATITIS AND HYPERTENSION: RELATIONSHIPS, INTERACTIONS, CORRECTION.

OBJECTIVE: The aim: To identify the relationships and interactions of the pain development in cases of patients with a combination of Chronic Pancreatits and Arterial Hypertension, with the next correction. PATIENTS AND METHODS: Materials and methods: We have conducted a comprehensive examination of 102 patients with a diagnosis of Chronic Pancreatitis in combination with stage II Arterial Hypertension during 2018-2020. The investigative contingent was divided by two study groups which depended from the treatment regimen. The first (I) group (n = 53) received basic therapy (BT) in accordance with the requirements of the relevant clinical protocols; the treatment of the second (II) group (n = 49) included the basic therapy with optimization (OT) by mineralocorrection (Zinc, Selenium, which have antioxidant properties), ω-3 polyunsaturated fatty acids and Folic Acid. The therapy duration was 8 weeks. RESULTS: Results: The performed regression analysis was mathematically substantiated the influence of the studied laboratory parameters of the inflammatory response and antioxidant system on the formation, dynamics of abdominal pain (the main clinical sign of CP) and the value of PAP (hypertensive vascular remodeling marker and risk predictor of cardiovascular events). The severity of abdominal pain is significantly influenced by leukocytes, ESR, α1-AT, cortisol, CRP, Bilirubin and Urea, and the value of PAP - CRP and selenium, from laboratory parameters of the inflammatory response and AOS. CONCLUSION: Conclusions: The effectiveness of the assigned optimized treatment scheme has been proven, which is indicated by the appearance of a reliable regression coefficient on the parameter of glutathione peroxidase after completion of treatment in comparison with patients used basic therapy.